The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production☆
Identifieur interne : 001842 ( Main/Exploration ); précédent : 001841; suivant : 001843The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production☆
Auteurs : Ronghua Zhang [République populaire de Chine] ; Kai Wang [République populaire de Chine] ; Wei Lv [République populaire de Chine] ; Wenjing Yu [République populaire de Chine] ; Shiqi Xie [République populaire de Chine] ; Ke Xu [République populaire de Chine] ; Wolfgang Schwarz [Allemagne, République populaire de Chine] ; Sidong Xiong [République populaire de Chine] ; Bing Sun [République populaire de Chine]Source :
- Biochimica et Biophysica Acta. Biomembranes [ 0005-2736 ] ; 2013.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical , chemistry : Viral Matrix Proteins.
- chemistry : Coronavirus 229E, Human.
- physiology : Coronavirus 229E, Human, Viral Matrix Proteins.
- Amino Acid Sequence, HEK293 Cells, Humans, Molecular Sequence Data, Protein Multimerization.
Abstract
In addition to a set of canonical genes, coronaviruses encode additional accessory proteins. A locus located between the spike and envelope genes is conserved in all coronaviruses and contains a complete or truncated open reading frame (ORF). Previously, we demonstrated that this locus, which contains the gene for accessory protein 3a from severe acute respiratory syndrome coronavirus (SARS-CoV), encodes a protein that forms ion channels and regulates virus release. In the current study, we explored whether the ORF4a protein of HCoV-229E has similar functions. Our findings revealed that the ORF4a proteins were expressed in infected cells and localized at the endoplasmic reticulum/Golgi intermediate compartment (ERGIC). The ORF4a proteins formed homo-oligomers through disulfide bridges and possessed ion channel activity in both
Url:
DOI: 10.1016/j.bbamem.2013.07.025
PubMed: 23906728
PubMed Central: 7094429
Affiliations:
- Allemagne, République populaire de Chine
- District de Darmstadt, Hesse (Land)
- Francfort-sur-le-Main
- Université Johann Wolfgang Goethe de Francfort-sur-le-Main
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Le document en format XML
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wicri:level="1"><nlm:aff id="af0005">Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123</wicri:regionArea><wicri:noRegion>Suzhou 215123</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0010">Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name><affiliation wicri:level="1"><nlm:aff id="af0010">Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Lv, Wei" sort="Lv, Wei" uniqKey="Lv W" first="Wei" last="Lv">Wei Lv</name><affiliation wicri:level="1"><nlm:aff id="af0010">Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Yu, Wenjing" sort="Yu, Wenjing" uniqKey="Yu W" first="Wenjing" last="Yu">Wenjing Yu</name><affiliation wicri:level="1"><nlm:aff id="af0010">Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Xie, Shiqi" sort="Xie, Shiqi" uniqKey="Xie S" first="Shiqi" last="Xie">Shiqi Xie</name><affiliation wicri:level="1"><nlm:aff id="af0010">Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name><affiliation wicri:level="1"><nlm:aff id="af0010">Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation></author><author><name sortKey="Schwarz, Wolfgang" sort="Schwarz, Wolfgang" uniqKey="Schwarz W" first="Wolfgang" last="Schwarz">Wolfgang Schwarz</name><affiliation wicri:level="4"><nlm:aff id="af0015">Goethe-University Frankfurt, Institute for Biophysics, Max-von-Laue-Str. 1, D-60438 Frankfurt am Main, Germany</nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea>Goethe-University Frankfurt, Institute for Biophysics, Max-von-Laue-Str. 1, D-60438 Frankfurt am Main</wicri:regionArea><placeName><region type="land" nuts="1">Hesse (Land)</region><region type="district" nuts="2">District de Darmstadt</region><settlement type="city">Francfort-sur-le-Main</settlement></placeName><orgName type="university">Université Johann Wolfgang Goethe de Francfort-sur-le-Main</orgName></affiliation><affiliation wicri:level="1"><nlm:aff id="af0020">Shanghai Research Center for Acupuncture and Meridian, 199 Guoshoujing Road, Shanghai 201023, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Shanghai Research Center for Acupuncture and Meridian, 199 Guoshoujing Road, Shanghai 201023</wicri:regionArea><wicri:noRegion>Shanghai 201023</wicri:noRegion></affiliation></author><author><name sortKey="Xiong, Sidong" sort="Xiong, Sidong" uniqKey="Xiong S" first="Sidong" last="Xiong">Sidong Xiong</name><affiliation wicri:level="1"><nlm:aff id="af0005">Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou 215123</wicri:regionArea><wicri:noRegion>Suzhou 215123</wicri:noRegion></affiliation></author><author><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><affiliation wicri:level="1"><nlm:aff id="af0010">Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200025</wicri:regionArea><wicri:noRegion>Shanghai 200025</wicri:noRegion></affiliation><affiliation wicri:level="1"><nlm:aff id="af0025">State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China</nlm:aff><country xml:lang="fr">République populaire de Chine</country><wicri:regionArea>State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031</wicri:regionArea><wicri:noRegion>Shanghai 200031</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biochimica et Biophysica Acta. Biomembranes</title><idno type="ISSN">0005-2736</idno><idno type="eISSN">1879-2642</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term><term>Coronavirus 229E, Human (chemistry)</term><term>Coronavirus 229E, Human (physiology)</term><term>HEK293 Cells</term><term>Humans</term><term>Molecular Sequence Data</term><term>Protein Multimerization</term><term>Viral Matrix Proteins (chemistry)</term><term>Viral Matrix Proteins (physiology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Cellules HEK293</term><term>Coronavirus humain 229E ()</term><term>Coronavirus humain 229E (physiologie)</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Multimérisation de protéines</term><term>Protéines de la matrice virale ()</term><term>Protéines de la matrice virale (physiologie)</term><term>Séquence d'acides aminés</term></keywords><keywords scheme="MESH" type="chemical" qualifier="chemistry" xml:lang="en"><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Coronavirus 229E, Human</term></keywords><keywords scheme="MESH" qualifier="physiologie" xml:lang="fr"><term>Coronavirus humain 229E</term><term>Protéines de la matrice virale</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Coronavirus 229E, Human</term><term>Viral Matrix Proteins</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term><term>HEK293 Cells</term><term>Humans</term><term>Molecular Sequence Data</term><term>Protein Multimerization</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Cellules HEK293</term><term>Coronavirus humain 229E</term><term>Données de séquences moléculaires</term><term>Humains</term><term>Multimérisation de protéines</term><term>Protéines de la matrice virale</term><term>Séquence d'acides aminés</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In addition to a set of canonical genes, coronaviruses encode additional accessory proteins. A locus located between the spike and envelope genes is conserved in all coronaviruses and contains a complete or truncated open reading frame (ORF). Previously, we demonstrated that this locus, which contains the gene for accessory protein 3a from severe acute respiratory syndrome coronavirus (SARS-CoV), encodes a protein that forms ion channels and regulates virus release. In the current study, we explored whether the ORF4a protein of HCoV-229E has similar functions. Our findings revealed that the ORF4a proteins were expressed in infected cells and localized at the endoplasmic reticulum/Golgi intermediate compartment (ERGIC). The ORF4a proteins formed homo-oligomers through disulfide bridges and possessed ion channel activity in both <italic>Xenopus</italic> oocytes and yeast. Based on the measurement of conductance to different monovalent cations, the ORF4a was suggested to form a non-selective channel for monovalent cations, although Li<sup>+</sup> partially reduced the inward current. Furthermore, viral production decreased when the ORF4a protein expression was suppressed by siRNA in infected cells. Collectively, this evidence indicates that the HCoV-229E ORF4a protein is functionally analogous to the SARS-CoV 3a protein, which also acts as a viroporin that regulates virus production. This article is part of a Special Issue entitled: Viral Membrane Proteins — Channels for Cellular Networking.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Masters, P" uniqKey="Masters P">P. Masters</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hamre, D" uniqKey="Hamre D">D. Hamre</name></author><author><name sortKey="Procknow, J J" uniqKey="Procknow J">J.J. 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Helenius</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Allemagne</li><li>République populaire de Chine</li></country><region><li>District de Darmstadt</li><li>Hesse (Land)</li></region><settlement><li>Francfort-sur-le-Main</li></settlement><orgName><li>Université Johann Wolfgang Goethe de Francfort-sur-le-Main</li></orgName></list><tree><country name="République populaire de Chine"><noRegion><name sortKey="Zhang, Ronghua" sort="Zhang, Ronghua" uniqKey="Zhang R" first="Ronghua" last="Zhang">Ronghua Zhang</name></noRegion><name sortKey="Lv, Wei" sort="Lv, Wei" uniqKey="Lv W" first="Wei" last="Lv">Wei Lv</name><name sortKey="Schwarz, Wolfgang" sort="Schwarz, Wolfgang" uniqKey="Schwarz W" first="Wolfgang" last="Schwarz">Wolfgang Schwarz</name><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><name sortKey="Sun, Bing" sort="Sun, Bing" uniqKey="Sun B" first="Bing" last="Sun">Bing Sun</name><name sortKey="Wang, Kai" sort="Wang, Kai" uniqKey="Wang K" first="Kai" last="Wang">Kai Wang</name><name sortKey="Xie, Shiqi" sort="Xie, Shiqi" uniqKey="Xie S" first="Shiqi" last="Xie">Shiqi Xie</name><name sortKey="Xiong, Sidong" sort="Xiong, Sidong" uniqKey="Xiong S" first="Sidong" last="Xiong">Sidong Xiong</name><name sortKey="Xu, Ke" sort="Xu, Ke" uniqKey="Xu K" first="Ke" last="Xu">Ke Xu</name><name sortKey="Yu, Wenjing" sort="Yu, Wenjing" uniqKey="Yu W" first="Wenjing" last="Yu">Wenjing Yu</name><name sortKey="Zhang, Ronghua" sort="Zhang, Ronghua" uniqKey="Zhang R" first="Ronghua" last="Zhang">Ronghua Zhang</name></country><country name="Allemagne"><region name="Hesse (Land)"><name sortKey="Schwarz, Wolfgang" sort="Schwarz, Wolfgang" uniqKey="Schwarz W" first="Wolfgang" last="Schwarz">Wolfgang Schwarz</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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